I carried and liked my 642 in .357 with 125 gr HP non +P loads in my pawnshop.
What I liked best was the muzzle blast. In practice at 7 yards indoor range, the blast would blow the paper target out almost horizontally.
Imagine the distraction for a bad guy if you did have to cut loose a SD round. Being INSIDE a muzzle flash could ruin your day. Not to mention the bullet.