I completely agree with Frank's post. I have owned several .22 LR pistols. Personally, had no luck with the Smith & Wesson 22a. Recently used a Mark III 22/45. Reliable, fun to shoot, most ammo wasn't a problem, but when I first handled the Ruger SR22 pistol, I knew I had to have it, Took it to the range yesterday and put about 200 rounds through it, All CCI. I have found that CCI is by far the best rimfire ammo on the market. Absolutely no FTF or FTE problems. As far as personal protection, I've only heard of people using these for concealed carry if they can't handle the recoil of large caliper pistols. My personal favorite is the Glock 23 in .40 caliber. Hope that helps clear some questions about the .22.