So far I think Im wanting a M&P15 sport and the Savage in 308. Are there any realistic things those two rifles cant do?
Aside from it being a pain to lug both around at the same time, no, there's not many reasonable ballistic problems one of those two could not be used to solve, given proper fodder....
As to your choice of .45ACP- if you like it, shoot it! It's my favorite pistol caliber, as well, but it has gotten expensive, even to handload. I Carry a 9mm now, for economic reasons- I have 5 kids and a gun collection to feed- every penny counts.