22 is not really any less dependable or reliable than any other cartridge. What is or does make a difference is the brand or quality of ammo you use with it.My ruger mark 2 will shoot jam free time and time again with good ammo. Use eceonmy ammo and you get just that, some good rounds,some not so good. The same goes for 9mm or 45acp or whatever.
22 I believe is just looked down upon due to its size. That as well is downplayed. Alot of people are killed every year by a 22 round. One must remember when reading off the internet or forums that alot of what is posted by people is nonsense and biased. Alot of people typing some of the stuff are less intelligent than the person researching on the other end.