There's a lot of good info. here in this thread:
a) check your local hunting laws as to bbl. and caliber restrictions
b) 41mag on up is capable of your quest. Limitations are usually the shooters not the pistol.
c) balance will shift even with as little as loaded cyl. Think what adding a scope will do.
d) muzzle heaviness is desired for a steady hold...
...would like to add that if you've never shot a scoped pistol that you try and borrow/rent one and shoot it before investing in a scope. I've bought a couple scopes from guys that just didn't care for scopes on pistols or couldn't get the hang of using them. A bit different compared to viewing from a scoped a long gun.