Hey there, this revolves around my persistent desire to eliminate leading in my revolvers.
You didn't say where your leading has occurred. Leading can be the result of many things, it isn't solely due to bullet diameter.
A really good reference can be found here.
On some of my revolvers, cutting the FC to 11 degrees and enlarging the cylinder throats eliminated leading with the correct hardness bullet driven at the proper velocity with the right burn rate powder. On others there may be light leading, but lead can be quite easy to remove if you have any using the correct tools. A Lewis Lead remover or a some strands of a copper Chore Boy wrapped around a brass brush does wonders after soaking overnight with Ed's Red (or Kroil).
A hard bullet driven too slowly, or a soft bullet driven too fast will lead. Just other things to consider.