How much experience does she have? How recoil sensitive is she? The LCR 357, even with .38 sp, can be pretty nasty. I've fired one, and I have lots of experience with a Smith & Wesson 442, which is an alloy J frame of similar weight. But then I'm a pretty high mileage handgun guy.
And as an NRA certified instructor I've introduced hundreds of beginners to shooting handguns. I would not recommend am LCR or alloy frame, small snub nose for a beginner. It's the sort of thing that will likely put a beginner off shooting.
If your wife is well schooled and experienced with a handgun, something like an LCR 357 could be a fine choice. But for a beginner, one of Ruger's medium frame revolvers with a steel frame and a 3 inch to 4 inch barrel would be a much better choice.
"It is long been a principle of ours that one is no more armed because he has possession of a firearm than he is a musician because he owns a piano. There is no point in having a gun if you are not capable of using it skillfully." -- Jeff Cooper