You may be able to attribute your V and H spreads to wind and mirage... takes a long time to learn how to dope both successfully.
You can play with sorting case weights, measuring the neck wall thickness as a sorting factor, match primer pockets (not clean, but actually match them with a cutter), invest in a bushing die, get or make some wind flags, use a more stable and repeatable shooting platform... the list goes on forever.
I've shot bazillions of .22-250. It's a very addicting and fun cartridge to play with. Sooner or later... you'll get frustrated with your current limits of accuracy and stick your whole foot, as opposed to only your current big toe, into benchrest methods and practices. Cha Ching!