When I was a kid I would occasionally would play with my dads 357 when he was away, I knew how to use guns because I was shown from a very young age how to shoot. I would unload the gun and then look at it, I was always very safe because I am writing this.
That being said, I lock all my guns at all times because I couldn't even think how I could live with myself if something happened to my kids and I could of prevented it by taking an extra step in securing it. I've seen experienced gun owners do stupid things without thinking, it just takes a split second. With the quick access lock boxes they sell today there's no reason not to. Just food for thought.
Guns don't kill people, the bullets do.