The old LRN (Lead Round Nose) tended to penetrate well but didn't expand. In addition, the bullet profile seemed to push the tissue aside leaving small sub-caliber wound channels and not much bleeding. It was an impressively poor self-defense round.
To expound on this I've found the old 158gr LRN load to be very good for small game (rabbits and squirrels) because they do so little tissue damage. The damage done to small game is less than that of some HV 22lr.