I used to be a huge fan of Unique and Bullseye, but after playing around with some of the newer powders out there, I won't be going back. Mainly just because they are so stinkin' dirty!
I recently started playing around with Trail Boss for lead bullets, and it is quickly becoming one of my favorite powders. I have found it to be very clean and accurate. And if you aren't trying produce fast loads(need to look at other powders for that), the pressures are much lower than other powders.