I'm not a varmit shooter, I'd be more in line with hogs or deer, so I shoot a little heavier bullet.
My Remington 780 in .243 loves:
Hornady 87 grain VMax over 37.5 grains Varget.
Hornady 95 grain SST over 35 grains Varget.
I tried IMR 4350 but did not get similar results. The Varget seems to be the powder of this guns choice.
I'm setting .035" off the lands.
I load, 9mm Luger, 38 and 40 S&W, 38 Special, 357Magnum, 45ACP, 45 Colt, 223, 300 AAC, 243 and 30-06