Good point about the evolution of ammo, Alaska444.
My two cents worth: if I was hunting around grizzly bears or hunting grizzly bears (either way), I don't think it would hurt to carry a 375 H&H (other than the weight of the gun). That way you would be ready for any eventuality, whether you are hunting the bear or vice versa. Talking about the cartridge's power is all fine and dandy, but heavy hitters are also just plain heavy. You have to hunt in pretty rough terrain to meet a grizzly, and packing a 13 lbs 460 Weatherby is typically not in the equation, so I would pick a rifle with a good trajectory, good energy, and not extremely heavy. Most 375s fit that description.