Largest? What is the largest animal can you find on the continental US?
Smallest? What's the smallest animal you can find on the continental US?
The real questions to be asked are the following:
How good are you with the weapon chambered in a .44mag?
What load are you using?
If you're shooting small critters do you want to actually be able to eat it after its been shot?
This is who we are, what we do.