Alliant has a single 2400 recipe load for 180 grain Speer Gold Dot bullets in the 10 mm Auto on their web site. The fact they list a 2400 load only for the heaviest bullet they test and the fact it uses the greatest number of grains of powder but does not achieve the highest velocity listed for that bullet, tells me 2400 is simply too slow burning for good efficiency in the amount of powder space available and with the range of bullet weights available in 10 mm Auto.
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