Been shooting 250 HP/XTP .452 @2100 fps for years. Never had one come apart. Never had to shoot anything past 140 yards yet, but at that range nothing moves out of it's tracks with a good shot.
Taken lots of deer and hogs with them, and for the most part I always get pass through shots on the deer, so I have not recovered the slug in any of the deer. I did take a between the eyes shot on a hog, that left the bullet inside of the animal, and even after going through the bones in the head, it was still in good