Unique. It covers light to medium loads easily and almost gets you into magnum territory. 2400 takes me into Magnum territory although rarely needed. That said, I have my favorite powders that I use in 'each' caliber. Red Dot in .357, Unique/universal in .44Spec, Unique in .44Mag, IMR 4227 in .45 Colt, and Bullseye in .45ACP.
A clinger. When guns are outlawed, only outlaws will have guns. Single Action .45 Colt (Sometimes improperly referred to by its alias as the .45 'Long' Colt or .45LC). Don't leave home without it. Ok.... the .44Spec is growing on me ... but the .45 Colt is still king.