I was sitting here trying to come up with an answer to the question. Trying to ask myself the "Which one would you pick for deer hunting if you could only pick one" kind of question. Which was leading me down the .257 Roberts line of thought. But really, the proper way to answer this question should be... Which cartridge have you actually used in the past to kill the most big game animals? Not the one you would use in the future. But in actual numerical count, which one have you used the most?
In my case, when that is the question, all the others fall out of the running by about a 5-1 margin. I bought a rifle way back in 1985 that seemed to me to be the ideal "do it all" kind of big game rifle and I really did use for all my big game hunting for about 15 years before I started using anything else. That would be a Remington 700 Classic in .350 Remington Magnum with a 4x Zeiss scope. So there you have it! Hard to beat the versatility of a mid-capacity .35 caliber.