I've got two .45-70s, an Italian clone of the Sharps business rifle, and a thoroughly modern H&R Handi rifle.
My go-to hunting rifle is a Savage 110 in .30-06.
I've got a dozen or so in the locker that I rotate betwixt. Everything from those single-shot Handi's to the bolt rifles, to the leverguns. Everything gets its turn.
But, my go-to rifle is the .30-06.