For most pistol rounds I use powders that meter well in my measure, and will drop to withing 0.1 grains ever single time. I will weigh quite a few charges when setting up the measure. Then I weigh maybe ever 20th or so.
For rifle rounds, and pistol powder that meters poorly I use a digiatal powder dispenser.
No matter how many times you do it and nothing happens it only takes something going wrong one time to kill you.