My favorite 270 load for the past decade or two (or maybe 3) is:
Remington cases (highly prepped)
CCI BR2 primers
130 gr Nosler Ballistic Tip
59 grains of H4831sc
The load is either over max or 1 gr under max, depending on what reloading book you use, so work up to it carefully. As for the bullet, it is destructive, which I sorta think explains why it's so effective, so avoid the edible parts of the deer. I just shoot em in the lungs. Works every time, and you have a pretty large 'kill zone' compared to shooting for the neck or the left eye or what have ya.