The Weatherby Magnum calibers look very, very enticing, although if you shoot a lot, you'll have to be prepared to deal with rarity. I personally don't mind oddball calibers thanks to this thing called the internet and of course there is also reloading.
I'd probably favor .270 Wby Mag for what you're describing. The Vanguards represent incredible values when used.
Mauser Werke, Schmidt-Rubin, Remington, Colt, H&K, Weatherby, Browning, Ruger, Marlin, Mossberg, Saiga, S&W, Sig Sauer....a few friends of mine