I can reload all of my carry guns one handed if need be. The thing is I do not carry a reload. I carry a second gun. That is between 18, and 21 rounds depending on which primary I am carrying. Though I can at the range reload them with one hand.
The only one that is challenging to reload with one hand is the Wildey Magnum. I definately am not going to try shooting it one handed. .357 Wildey Mag in not a wimpy round. (.475 Wildey Mag necked down to .358) It shoots 180 grain bullets at holy canoli velocities. Recoil is enugh to want to hang on with both hands.
No matter how many times you do it and nothing happens it only takes something going wrong one time to kill you.