I had a Remington standard SR primer that was mistakenly used in a .223 Rem case. It pierced, Left some cabon on the bolt face of my Savage. as well as a black smear on the firing pin. Also I had to use a cleaning rod to extract the case.
As far as Large I am not sure, I am led to believe that Large Rifle Primers are taller than Large Pistol Primers. Using a pistol in place of the rife the primer may be too deep for the firing pin to strike.
No matter how many times you do it and nothing happens it only takes something going wrong one time to kill you.