Ballistics of the 22LR and 25ACP are about the same and good quality modern 22LR ammo is reliable, so they are about equal in results. The shooter is the weak link in the system. Bullet placement is absolutely critical with these tiny carteidges and 22LR ammo is a fraction of the cost of 25ACP. Unless you have a very large ammunition budget, you will never practice enough with a .25 to be able to use it effectively.
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