Really want to go on a Bison Hunt.
I have yet to hunt Bison but it is definitely on my bucket list.
Now, I think old warbird was really just wanting to "stir the pot" with his 22-250 question but I would definitely say NO.
I have talked with one of the ranchers on the S. Dakota/Montana border that offer hunts. While he suggested the big magnums, he did agree that .270 and .30-06 in the hands of a skilled shooter would definitely do the job. He also told me to practice at 200-300 yds because despite these Bison being 'ranch raised' they remained averse to people and very wary.