BIL shot his last fall in SD with a .300 Win Mag 200 gr. through the heart. The other Buffalo get around an injured one and that buffalo stood "dead on his feet" for almost 1/2 hour!! He couldn't shoot it again because of that. They are some TOUGH animals.
You see the pics of indians shooting them with bows and arrows? That's a crock. They used to run the herd off a cliff!