The .22-250 will fell even a big MT Mulie with one well placed shot, as long as you use make good ammo choices, and pass on bad shot angles. The .17Rem....I know it gets done, I even know a local who has killed several does, a mountain lion, a few bobcats, and many coyotes with one, but I can't quite get myself past the fact that my childhood pellet gun was a .17.
You'll probably never NEED a gun. I hope you never do. But IF you do, you will need it worse than anything you've ever needed in your life.
IF we're not supposed to eat animals,
howcome God made 'em outta meat?