I just loaded my first 50 38s. I will tell you that once you get set up and get going everything starts making since. I bought some cheap calipers and a good digital scale before I ever started but I was scared to death that I'd blow up my favorite gun and my favorite hand. You'll probably flinch the first time you pull the trigger but you'll be fine.
Also don't just stick to light 38s, load some rounds to take advantage of that ruger!
Someday I'll be good enough to know if a gun is accurate or not.