Many people on the 'Net and on the stools at your LGS seem to believe that .22LR bullets tumble wildly in tissue and bounce around like a pinball when they hit bone, but this isn't necessarily the case.
Yes, they will
yaw and bounce, but so do other commonplace pistol rounds when conditions are right. It's not some magic .22LR-only thing.
I prefer to think that the performance difference between .22LR and .25ACP amounts to splitting hairs.