My problem with using big and powerful guns on animals is it destroys a lot of meat. In my opinion, a .243 does a lot of damage. Some guys use .300 mags and its way excessive.
When i hunt in WV i take the deer to a processor who is a long time friend. By noon the first day of hunting season there are rows of deer awaiting processing. i always walk down the rows; amazed at how badly some are shot up. It's not unusual to see a deer thats been shot through both hams and both shoulders. When you look at the tags; the vast majority of shot up deer were killed by out of state hunters.
Most WV hunters pick their shots carefully and lose very little meat. The owner tells me hunters often get incensed when they get their shot up deer back in one grocery bag.