I'm a bit fond of cannons and essentially lazy. Tracking game through 300 yds of dense brush isnt exactly my cup of tea. I prefer that the game drop within 50 yards or so. Since I quit hunting with the smaller cartridges all my game has remained within 50 yds of impact. Yes, I get as close as I can and yes, I put the bullet through the vitals. Ive had to track deer shot in the heart with 150 gr corelokt 06 for about a quarter of a mile (its amazing what they can do) but with the 300, 50 yds has been the limit.
Interior damage is much different too. With the 06, damage was kept close to the bullet channel. With the 300, internal organs were all damaged.
To each their own.
No such thing as a stupid question. What is stupid is not asking it.