Shooting a squirrel with a 12ga will destroy meat! If the squirrel is with in 10 feet. Other wise it works great! I typically just use trap load such as 7 1/2 or 8
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 25 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple