While I believe the safest course of action for all is to post up, call 911, and defend from a single point if there were an intruder or intruders in your residence, I also understand circumstances may present themselves and this may not be an option e.g., someone is hurt or being attacked, family in other rooms, etc...
For the folks with dogs, try going through your house with one at your side. It's fun to play and the dogs love it. Mine does anyway. It's fun giving the command to go into a room or upstairs and watch him actually do it then follow him through.