Trail Boss had done well with cast bullets in every gun I have loaded for with it. Now it does not get scorcher velocities, it does help me to make one ragged hole in a taget, or to knock down steel targets all day long.
If you hand weigh the charges HiSkor 800X may do fairly well. I have had good results with it in .45 acp with cast lead semiwadcutters.
No matter how many times you do it and nothing happens it only takes something going wrong one time to kill you.