Yes, that concern regards chronic wasting disease, a close relative of mad cow disease, thought to be transmitted by tiny protein fragments (called prions) in neural tissue. It can be moved around by contact (knife blade, hand, etc.) with infected neural tissue. Theoretically, one could dispatch an infected animal with a head shot, skin it without contacting any damaged tissue (including splatters), discard the head and skin and be safe. In Ohio, we haven't seen CWD yet.