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Distance is very important to consider here. Large open rooms (or outdoor/garage situations) might require #1 or 00. In my apartment building (and many small homes), 20ft is much farther than any realistic shot. Heck, 6 ft is probably farther than any defensive shot would be in my tiny apartment. Now, at that distance, I don't think there is a commonly sold 12ga round that would not drop a man with a center mass shot.
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