So is it OK for a gun to wear out eventually? (rhetorical question) The alternative is to not shoot it.
The guns I shoot often are treated as tools, cared for but well used.
However, I don't use screwdrivers as prybars. I understand that a Ruger is cheap to replace, not like the OP is wanting them for a $1500 Python but if your going for "beyond published" why not get a Contender? Not only would it cost about the same but, It will last forever with hot 357's. Heck you could get really impressive numbers if you also had a 357 Max barrel.