As others have said it is certainty doable if you do your part. I shot a 120lb doe this season using a MFS 62gr, granted I was only at 35yds but I was impressed with the damage that it did. The round broke right shoulder bone, broke a right side rib, turned the top of the heart and the tips of both lungs into jello, broke a left side rib and kept on going. The only trace of the bullet I found was small 1/4" piece of the jacket. I have photos of the carnage if anyone to see them.
The doe fell backwards and made it about 4' from where I shot her, blood all over the place.
Anything other 100yds I feel would be pushing it but if you hunt in an area like mine anything over 75yds is a long shot.
And yes I know that is a 30rd mag and yes it was blocked to 5 rounds. I didn't get a 5rd mag ordered before deer season.