If you see wolves in a zoo they are usually well fed and very big, wolves in Idaho are nearly as well fed and they get exercise to build muscle mass. They are naturally going to tend toward the larger end of the species
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 23 of my guns are 45/70 govt 357 mag, 22 or 12 ga... I believe in keeping it simple