Here in Idaho where the wolves have lots of elk/deer/sheep/calves to eat they get pretty big. I suspect in areas where there is less for them to eat they may not get as big.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 23 of my guns are 45/70 govt 357 mag, 22 or 12 ga... I believe in keeping it simple