Autoloaders with a "magazine disconnect" require that a magazine be inserted before the action will operate. As a result, you'd have to insert a magazine to function check the gun or to drop the hammer or striker (assuming of course it did not have a decocker).
Some refer to this device as a "magazine safety" but this is one example of who this can make the gun less safe.
I won't mention how a lost or damaged magazine would render the operator defenseless. I suppose that is "safe" for the attacker but not so "safe" for the operator.
In the final analysis the only reliable "safety" resides between the ears of the responsible gun owner.