I've tagged some two dozen bucks with my .243. Being lazy, I've used the same bullet for deer as for coyotes: The Sierra 85-grain HPBT. I was very picky about my shots, though, and only went for neck shots or cross-body heart/lung shots. I would never take an angling shot with that blow-up bullet.
However, a typical 100-grain bullet would penetrate at an angle, such that proper placement would provide a clean kill.
You're from BATFE? Come right in! I use all your fine products!