Some of you might recall this story from other posts: The absolutely most destructive load I've ever seen was my uncle's load of an 80-grain .32-20 bullet, swaged down to 30-caliber and laoded into an '06 ahead of a lot of 3031. I'd guesstimate a muzzle velocity close to 3,800 or so.
On coyote-sized stuff, or on down to jackrabbits and suchlike, it's sorta like using a hand grenade. It makes bodily parts go all whichaways. Do not, repeat, do not, shoot overhead into a buzzard.
but I was 16 at the time; fortunately I was not only agile, but speedy--and that day, I had incentive.