As long as they size away your fine , but if they start growing "wings" on the nose then it`s time to clean the mold good & clean & relube it with Bullshop`s Bull Plate Lube .
Also after cleaning look for worn battered alumilum in places it should`nt be .
I own many of Lee`s 2holer moulds & I started along time ago placeing em on a flat surface to close en ,it keeps em level & more square while they mate together.
The 6 cavitys have steel inserts for alignment & stand up to a little heavy handedness better ,but still need bull plate lube !
Short answer ,yes your chasin ghosts to a point .
The bullet will fly true as long as it`s balanced even an oval one.