For a NIB defense caliber home defense gun on a budget it is hard to beat a Sig SP2022. They run about $350. NIB. No manual safety but a stiff enough DA/SA trigger so it should not be a safety issue.
If you are open to used guns then I would look at the CZ75B, Beretta 92FS & 3rd Gen S&Ws. The CZ is a $400 gun and the S&W are $300 to $400 depending on configuration. I also 2nd the 92FS which is a $400 used gun.
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