I have laoded a few hundred of them. and they worked just fine with my cast bullet loads. I save then up till I have a coffee can full of them. I also load for 9mm so I keep a supply of small pistol primers on hand. I load them with the same charge of Bull's Eye that I use for large pistol primers. I have not noticed a differance.
No matter how many times you do it and nothing happens it only takes something going wrong one time to kill you.