I use a 357 magnum lever action shooting solid bullets.
of course the 357 magnum lever action in my answer to most things under 100-150 LBS.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 26 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple. Wish my wife did as well...