Aw, c'mon, ER--ya call ol' Wiley in close enough, you can head-shoot him with a .22 rimfire!
But I've never had trouble with group-size with the 110-grain bullets; I guess it's "the twist thing".
Dr. Rob, I've come to believe the Sierra 150- and 165-grain boat-tails must have rather thin jackets. You may have read my comments about no exit on a mule deer's neck with the 150. I once shot a doe with the 165-grain (60 yards, +/-) and you could stick your fist into the exit wound.