I have killed more deer (as well as my first deer) with a 357 magnum Marlin lever action.
My favorite is probably the 45/70 (all so a Marlin) but the wife gets mad when I shoot those in the back yard.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 23 of my guns are 45/70 govt 357 mag, 22 or 12 ga... I believe in keeping it simple